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0 · ziltivekimab side effects
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2 · ziltivekimab heart failure
3 · aimovig study results
4 · Hermes trial stroke
5 · Hermes trial heart failure
6 · Hermes stroke
7 · Hermes collaboration
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The HERMES trial is an international, multicentre, parallel group, randomized, double-blind, study in patients with HFpEF and HFmrEF, evaluating the effect of ziltivekimab 15mg compared with . Methods: We formed the HERMES collaboration to pool patient-level data from five trials (MR CLEAN, ESCAPE, REVASCAT, SWIFT PRIME, and EXTEND IA) done between December, 2010, and December, 2014. In . Our study provides clear evidence that in clinical practice, endovascular therapy for stroke should not be withheld on the basis of advanced age, moderately extensive early . The study investigators established the Highly Effective Reperfusion Evaluated in Multiple Endovascular Stroke Trials (HERMES) collaboration to undertake meta-analysis of .
The study represents the first focused investigation into the association between endovascular treatment and functional outcomes in patients with acute isolated intracranial internal carotid artery (ICA‐I) occlusion in a .
Basel, November 2, 2020 — Novartis announced today that HER-MES, the first Phase IV, randomized, double-blind, double-dummy, head-to-head study of Aimovig ® (erenumab) . The HERMES study sought to characterize the period in which endovascular thrombectomy is associated with benefit and the extent to which treatment delay is related to .
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Background: We compared the tolerability and efficacy of erenumab, a monoclonal antibody binding to the calcitonin gene-related peptide receptor, to topiramate for migraine prophylaxis .
Objective: HER-MES was the first head-to-head, phase 4 trial to assess the tolerability and effectiveness of erenumab against standard of care treatment (topiramate). . In HERMES (Highly Effective Reperfusion Evaluated in Multiple Endovascular Stroke trials) pooled randomized clinical trial data, among 801 EVT patients, partial reperfusion .The HERMES trial is an international, multicentre, parallel group, randomized, double-blind, study in patients with HFpEF and HFmrEF, evaluating the effect of ziltivekimab 15mg compared with placebo, given once a month, in addition to standard care, on the primary composite outcome of time to first occurrence of cardiovascular death, heart .
Methods: We formed the HERMES collaboration to pool patient-level data from five trials (MR CLEAN, ESCAPE, REVASCAT, SWIFT PRIME, and EXTEND IA) done between December, 2010, and December, 2014. In these trials, patients with acute ischaemic stroke caused by occlusion of the proximal anterior artery circulation were randomly assigned to .
Our study provides clear evidence that in clinical practice, endovascular therapy for stroke should not be withheld on the basis of advanced age, moderately extensive early ischaemic changes on baseline CT, and moderate or severe clinical deficit.The study investigators established the Highly Effective Reperfusion Evaluated in Multiple Endovascular Stroke Trials (HERMES) collaboration to undertake meta-analysis of pooled individual patient data. The study represents the first focused investigation into the association between endovascular treatment and functional outcomes in patients with acute isolated intracranial internal carotid artery (ICA‐I) occlusion in a randomized controlled setting within the highly effective reperfusion evaluated in multiple endovascular stroke trials .Basel, November 2, 2020 — Novartis announced today that HER-MES, the first Phase IV, randomized, double-blind, double-dummy, head-to-head study of Aimovig ® (erenumab) against topiramate, an anticonvulsant, in patients with episodic and chronic migraine met its primary and secondary endpoints.
The HERMES study sought to characterize the period in which endovascular thrombectomy is associated with benefit and the extent to which treatment delay is related to functional outcomes, mortality, and symptomatic intracranial hemorrhage.Background: We compared the tolerability and efficacy of erenumab, a monoclonal antibody binding to the calcitonin gene-related peptide receptor, to topiramate for migraine prophylaxis in adults. Methods: HER-MES was a 24-week, randomised, double-blind, double-dummy, controlled trial conducted in 82 sites in Germany.
Objective: HER-MES was the first head-to-head, phase 4 trial to assess the tolerability and effectiveness of erenumab against standard of care treatment (topiramate). This post hoc analysis compared the efficacy of erenumab with topiramate in patients who completed the trial on study medication. In HERMES (Highly Effective Reperfusion Evaluated in Multiple Endovascular Stroke trials) pooled randomized clinical trial data, among 801 EVT patients, partial reperfusion was frequent, present in 80% of patients, including expanded TICI (eTICI) 2a (1%–49% reperfusion) in 14%, eTICI 2b50 (50%–66% reperfusion) in 14%, eTICI 2b67 (67%–89% .The HERMES trial is an international, multicentre, parallel group, randomized, double-blind, study in patients with HFpEF and HFmrEF, evaluating the effect of ziltivekimab 15mg compared with placebo, given once a month, in addition to standard care, on the primary composite outcome of time to first occurrence of cardiovascular death, heart . Methods: We formed the HERMES collaboration to pool patient-level data from five trials (MR CLEAN, ESCAPE, REVASCAT, SWIFT PRIME, and EXTEND IA) done between December, 2010, and December, 2014. In these trials, patients with acute ischaemic stroke caused by occlusion of the proximal anterior artery circulation were randomly assigned to .
Our study provides clear evidence that in clinical practice, endovascular therapy for stroke should not be withheld on the basis of advanced age, moderately extensive early ischaemic changes on baseline CT, and moderate or severe clinical deficit.The study investigators established the Highly Effective Reperfusion Evaluated in Multiple Endovascular Stroke Trials (HERMES) collaboration to undertake meta-analysis of pooled individual patient data. The study represents the first focused investigation into the association between endovascular treatment and functional outcomes in patients with acute isolated intracranial internal carotid artery (ICA‐I) occlusion in a randomized controlled setting within the highly effective reperfusion evaluated in multiple endovascular stroke trials .
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Basel, November 2, 2020 — Novartis announced today that HER-MES, the first Phase IV, randomized, double-blind, double-dummy, head-to-head study of Aimovig ® (erenumab) against topiramate, an anticonvulsant, in patients with episodic and chronic migraine met its primary and secondary endpoints.
The HERMES study sought to characterize the period in which endovascular thrombectomy is associated with benefit and the extent to which treatment delay is related to functional outcomes, mortality, and symptomatic intracranial hemorrhage.
Background: We compared the tolerability and efficacy of erenumab, a monoclonal antibody binding to the calcitonin gene-related peptide receptor, to topiramate for migraine prophylaxis in adults. Methods: HER-MES was a 24-week, randomised, double-blind, double-dummy, controlled trial conducted in 82 sites in Germany. Objective: HER-MES was the first head-to-head, phase 4 trial to assess the tolerability and effectiveness of erenumab against standard of care treatment (topiramate). This post hoc analysis compared the efficacy of erenumab with topiramate in patients who completed the trial on study medication.
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hermes study|ziltivekimab side effects
